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Last Updated: April 25, 2024

Patent: 6,309,859

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Summary for Patent: 6,309,859

Title:	Method for removing N-terminal methionine
Abstract:	The present invention provides a method for chemically removing a N-terminal methionine residue selectively, specifically and efficiently from a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal. The method reacts a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal with an .alpha.-diketone derivative, followed by hydrolysis.
Inventor(s):	Nishimura; Osamu (Hyogo, JP), Suenaga; Masato (Hyogo, JP), Ohmae; Hiroaki (Nara, JP), Tsuji; Shinji (Hyogo, JP)
Assignee:	Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:	09/436,518
Patent Claims:	see list of patent claims

Details for Patent 6,309,859

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	01/16/1978	⤷ Try a Trial	2016-06-14
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2016-06-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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