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Last Updated: March 29, 2024

Patent: 6,250,469


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Summary for Patent: 6,250,469
Title: Formulations for protection of peg-interferon alpha conjugates
Abstract:The present invention provides formulations that prevent loss and damage of PEG-interferon alpha conjugates during and following lyophilization. The formulations of the present invention protect PEG-interferon alpha conjugates from loss and degradation during the lyophilization process, as well as degradation during subsequent storage. The formulations of the present invention are suitable for protection of PEG-interferon alpha conjugates from various types of degradation, including, but not limited to loss of biological activity and changes in the degree and/or nature of conjugation. A preferred PEG-interferon alpha conjugate protectable in the formulations of the present invention is an interferon alpha-2b-polyethylene glycol (12,000) conjugate.
Inventor(s): Kline; Douglas (New York, NY)
Assignee: Schering Corporation (Kenilworth, NJ)
Application Number:09/703,581
Patent Claims:see list of patent claims

Details for Patent 6,250,469

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. PEGINTRON peginterferon alfa-2b Injection 103949 01/19/2001 ⤷  Try a Trial 2018-03-26
Merck Sharp & Dohme Corp. SYLATRON peginterferon alfa-2b For Injection 103949 03/29/2011 ⤷  Try a Trial 2018-03-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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