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Generated: August 18, 2019

DrugPatentWatch Database Preview

Patent: 5,814,460

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Summary for Patent: 5,814,460
Title: Method for generating and screening useful peptides
Abstract:The invention allows the generation and screening of a large population of peptides for the presence of peptides which bind a particular macromolecule or macromolecular complex with high affinity, and further allows the favored net synthesis of analyzable quantities of such peptides, by using is the \"trap\" a macromolecule or macromolecular complex for which binding of the peptide is desired. The starting mixture is preferably spiked with a peptide having some affinity for the target macromolecule so that mutation of the spike or \"lead\" peptide is favored. The development of improved binding peptides through scrambling may be dynamically monitored by initially binding the target with an insolubilized ligand, and then looking for an increase in the concentration of the target in the soluble phase as a result of the displacement of the reference ligand by scrambled peptides.
Inventor(s): Venton; Duane L. (Lombard, IL), Hopfinger; Anton J. (Lake Forest, IL), Lebreton; Guy (Oak Park, IL)
Assignee: Diatide, Inc. (Londonderry, NH)
Application Number:08/387,749
Patent Claims:see list of patent claims

Details for Patent 5,814,460

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Sign Up Diatide, Inc. (Londonderry, NH) 2015-09-29 RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source

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Mallinckrodt
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Cantor Fitzgerald
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Chubb
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