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Last Updated: April 16, 2024

Patent: 5,747,453

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Summary for Patent: 5,747,453

Title:	Method for increasing the electrotransport flux of polypeptides
Abstract:	Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming .alpha.-helical or .beta.-sheet segments. In particular, amino acid residues known to stabilize .alpha.-helical and .beta.-sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided.
Inventor(s):	Holladay; Leslie A. (Mountain View, CA), Oldenburg; Kevin R. (Fremont, CA)
Assignee:	ALZA Corporation (Palo Alto, CA)
Application Number:	08/468,275
Patent Claims:	see list of patent claims

Details for Patent 5,747,453

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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