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Last Updated: March 28, 2024

Patent: 5,714,313


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Summary for Patent: 5,714,313
Title: Simple method for detecting inhibitors of retroviral replication
Abstract:The present invention relates, in general, to a DNA segment. In particular, the present invention relates to a DNA segment comprising a selectable marker gene, a DNA segment comprising a selectable marker gene inserted into a retrotransposon, cells containing these DNA segments, and methods of using these DNA segments and cells. The present invention further relates to a vector comprising a selectable marker gene inserted into a retrotransposon, wherein the retrotransposon comprises a retroviral reverse transcriptase/RNase H gene domain and wherein the selectable marker gene contains an intron inserted into a coding sequence of the marker gene and the intron is in antisense orientation relative to transcription of the marker gene and in sense orientation relative to transcription of the retrotransposon.
Inventor(s): Garfinkel; David J. (Frederick, MD), Nissley; Dwight V. (Frederick, MD), Curcio; Joan M. (Albany, NY), Strathern; Jeffrey N. (Frederick, MD)
Assignee: United States of America as represented by the Department of Health and (Washington, DC)
Application Number:08/449,207
Patent Claims:see list of patent claims

Details for Patent 5,714,313

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2015-02-03
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2015-02-03
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2015-02-03
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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