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Last Updated: April 24, 2024

Patent: 5,686,262

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Summary for Patent: 5,686,262

Title:	Recycle process for the production of low-cost soluble collagen
Abstract:	The invention includes a method that provides a low cost aqueous solution of solubilized collagen by the steps of: (a) providing an aqueous ground slurry of insoluble collagen and adjusting the pH of said slurry to obtain activity for a proteolytic enzyme added in Step b; (b) adding said proteolytic enzyme to said pH adjusted slurry; (c) reacting the slurry and enzyme of Step b and/or recycled insoluble collagen and enzyme from Step e at a temperature, T, and for a time, t, effective for forming a solution increased in solubilized collagen; (d) adding additional water and insoluble collagen to said solution of Step c and mixing; (e) separating at least some of the solution of Step d containing solubilized collagen from insoluble collagen, whereby at least a portion of said insoluble collagen and proteolytic enzyme is recycled to Step c, and the separated solution containing solubilized collagen is withdrawn as product; an alternative embodiment provides for the direct production of solubilized collagen without the recycle step.
Inventor(s):	Fink; David J. (Shaker Heights, OH), Brody; Richard S. (Worthington, OH)
Assignee:	Ranpak Corporation (Concord, OH)
Application Number:	08/488,368
Patent Claims:	see list of patent claims

Details for Patent 5,686,262

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Discure Medical, Llc	CHYMODIACTIN	chymopapain	For Injection	018663	11/10/1982	⤷ Try a Trial	2014-11-11
Discure Medical, Llc	CHYMODIACTIN	chymopapain	For Injection	018663	08/21/1984	⤷ Try a Trial	2014-11-11
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2014-11-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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