Patent: 5,424,208
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Summary for Patent: 5,424,208
Title: | Method for isolating cells from tissue with a composition containing collagenase and chymopapin |
Abstract: | Proteolytic enzyme compositions and processes for digesting connective tissue are provided. The enzyme compositions include collagenase, which is essentially free of toxins and non-collagen specific components, and chymopapain, which is essentially free of toxins. The enzyme compositions are used for dissociating microvessel cells from connective tissue. Recovered microvessel cells are incorporated into artificial vessel grafts. The composition preferrably contains collagenase having an activity of about 43 nkat/ml to about 51 nkat/ml and chymopapin having an activity of about 0.22 nkat/ml to about 0.44 nkat/ml. |
Inventor(s): | Lee; Catherine T. (Laguna Hills, CA), Hornacek; Cynthia (Trabuco Cyn, CA), Dinh; Tan T. (Garden Grove, CA) |
Assignee: | Baxter International Inc. (Deerfield, IL) |
Application Number: | 08/311,383 |
Patent Claims: | see list of patent claims |
Details for Patent 5,424,208
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Discure Medical, Llc | CHYMODIACTIN | chymopapain | For Injection | 018663 | 11/10/1982 | ⤷ Try a Trial | 2013-04-16 |
Discure Medical, Llc | CHYMODIACTIN | chymopapain | For Injection | 018663 | 08/21/1984 | ⤷ Try a Trial | 2013-04-16 |
Smith & Nephew, Inc. | SANTYL | collagenase | Ointment | 101995 | 06/04/1965 | ⤷ Try a Trial | 2013-04-16 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |