Patent: 10,702,611
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Summary for Patent: 10,702,611
| Title: | Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates |
| Abstract: | Examples may include a method of making a protein-PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein solution. This aqueous protein solution may include a protein and a pH buffer. The method may also include reacting a polyethylene glycol with the protein to form a protein-PEG conjugate. The method may further include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid in an organic phase. The protonation may form the protein-PEG conjugate salt having a hydrophobic anion that increases the hydrophobicity-PEG conjugate salt. |
| Inventor(s): | Rosendahl; Mary S. (Broomfield, CO), Mantripragada; Sankaram B. (Windsor, CO), Gomez; Eliana B. (Boulder, CO) |
| Assignee: | Rezolute, Inc. (Redwood City, CA) |
| Application Number: | 16/032,952 |
| Patent Claims: | see list of patent claims |
Details for Patent 10,702,611
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Nps Pharmaceuticals, Inc. | NATPARA | parathyroid hormone | For Injection | 125511 | 01/23/2015 | ⤷ Try a Trial | 2034-12-02 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
