Patent: 10,123,996
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Summary for Patent: 10,123,996
Title: | Macrocyclic lactone compounds and methods for their use |
Abstract: | A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, R.sup.8, M.sup.1, M.sup.2, M.sup.3, M.sup.4, M.sup.5, M.sup.6 and M.sup.7 are each independently a member selected from the group consisting of H, C.sub.1-6 alkyl, OH and C.sub.1-6 hydroxyalkyl; R.sup.4, R.sup.7 and R.sup.9 are each independently selected from the group consisting of C.sub.1-6 alkoxy and OH; R.sup.10 is a member selected from the group consisting of H, --OH, --OP(O)Me.sub.2, ##STR00002## --O--(CH.sub.2).sub.n--OH and --O--(CH.sub.2).sub.m--O--(CH.sub.2).sub.o--CH.sub.3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L.sup.1 and L.sup.4 are independently selected from the group consisting of: ##STR00003## wherein each M.sup.8 is independently a member selected from the group consisting of C.sub.1-6 alkyl, OH and C.sub.1-6 hydroxyalkyl; each of L.sup.2 and L.sup.3 are independently selected from the group consisting of: ##STR00004## and salts, isomers, or N-oxides thereof. |
Inventor(s): | Yan; John (Los Gatos, CA), Zheng; Xiaoxia (Mountain View, CA), Bhat; Vinayak D. (Cupertino, CA) |
Assignee: | Elixir Medical Corporation (Milpitas, CA) |
Application Number: | 15/181,284 |
Patent Claims: | see list of patent claims |
Details for Patent 10,123,996
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genentech, Inc. | AVASTIN | bevacizumab | Injection | 125085 | 02/26/2004 | ⤷ Try a Trial | 2026-09-13 |
Genentech, Inc. | LUCENTIS | ranibizumab | Injection | 125156 | 06/30/2006 | ⤷ Try a Trial | 2026-09-13 |
Genentech, Inc. | LUCENTIS | ranibizumab | Injection | 125156 | 08/10/2012 | ⤷ Try a Trial | 2026-09-13 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |