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Last Updated: March 3, 2021

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Patent: 10,123,996

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Summary for Patent: 10,123,996
Title:Macrocyclic lactone compounds and methods for their use
Abstract: A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, R.sup.8, M.sup.1, M.sup.2, M.sup.3, M.sup.4, M.sup.5, M.sup.6 and M.sup.7 are each independently a member selected from the group consisting of H, C.sub.1-6 alkyl, OH and C.sub.1-6 hydroxyalkyl; R.sup.4, R.sup.7 and R.sup.9 are each independently selected from the group consisting of C.sub.1-6 alkoxy and OH; R.sup.10 is a member selected from the group consisting of H, --OH, --OP(O)Me.sub.2, ##STR00002## --O--(CH.sub.2).sub.n--OH and --O--(CH.sub.2).sub.m--O--(CH.sub.2).sub.o--CH.sub.3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L.sup.1 and L.sup.4 are independently selected from the group consisting of: ##STR00003## wherein each M.sup.8 is independently a member selected from the group consisting of C.sub.1-6 alkyl, OH and C.sub.1-6 hydroxyalkyl; each of L.sup.2 and L.sup.3 are independently selected from the group consisting of: ##STR00004## and salts, isomers, or N-oxides thereof.
Inventor(s): Yan; John (Los Gatos, CA), Zheng; Xiaoxia (Mountain View, CA), Bhat; Vinayak D. (Cupertino, CA)
Assignee: Elixir Medical Corporation (Milpitas, CA)
Application Number:15/181,284
Patent Claims:see list of patent claims

Details for Patent 10,123,996

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech LUCENTIS ranibizumab INJECTABLE; INJECTION 125156 001 2006-06-30   Start Trial Elixir Medical Corporation (Milpitas, CA) 2026-09-13 RX search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26   Start Trial Elixir Medical Corporation (Milpitas, CA) 2026-09-13 RX search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Start Trial Elixir Medical Corporation (Milpitas, CA) 2026-09-13 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 10,123,996

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 2008033956   Start Trial
United States of America 10695327   Start Trial
United States of America 2008138375   Start Trial
United States of America 2008234309   Start Trial
United States of America 2011097364   Start Trial
United States of America 2012071500   Start Trial
>Country >Patent Number >Estimated Expiration

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Serving leading biopharmaceutical companies globally:

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Johnson and Johnson
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Boehringer Ingelheim
AstraZeneca

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