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Last Updated: April 19, 2024

Patent: 10,092,659

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Summary for Patent: 10,092,659

Title:	Duocarmycin ADCs for use in treatment of endometrial cancer
Abstract:	The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumors expressing HER2, wherein the human solid tumor expressing HER2 is endometrial cancer, in particular uterine serous carcinoma (USC). In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of endometrial cancer, notably USC, with HER2 IHC 2- or 1+ and HER2 FISH negative tumor tissue status.
Inventor(s):	Santin; Alessandro Davide (New Haven, CT), Goedings; Peter Johannes (Nijmegen, NL)
Assignee:	Synthon Biopharmaceuticals B.V. (Nijmegen, NL) Yale University (New Haven, CT)
Application Number:	15/216,366
Patent Claims:	see list of patent claims

Details for Patent 10,092,659

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998	⤷ Try a Trial	2034-01-10
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017	⤷ Try a Trial	2034-01-10
Genentech, Inc.	PERJETA	pertuzumab	Injection	125409	06/08/2012	⤷ Try a Trial	2034-01-10
Genentech, Inc.	HERCEPTIN HYLECTA	trastuzumab and hyaluronidase-oysk	Injection	761106	02/28/2019	⤷ Try a Trial	2034-01-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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