Self-regulated peptide hydrogel for insulin delivery
A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients\' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia.
Langer; Robert S. (Newton, MA), Anderson; Daniel G. (Sudbiry, MA), Gu; Zhen (Cambridge, MA), Aimetti; Alex Arthur (Waltham, MA)
Massachusetts Institute of Technology (Cambridge, MA) The Children\'s Medical Center Corporation (Boston, MA)
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