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Last Updated: March 29, 2024

Patent: 9,994,615


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Summary for Patent: 9,994,615
Title:Self-regulated peptide hydrogel for insulin delivery
Abstract: A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients\' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia.
Inventor(s): Langer; Robert S. (Newton, MA), Anderson; Daniel G. (Sudbiry, MA), Gu; Zhen (Cambridge, MA), Aimetti; Alex Arthur (Waltham, MA)
Assignee: Massachusetts Institute of Technology (Cambridge, MA) The Children\'s Medical Center Corporation (Boston, MA)
Application Number:14/379,477
Patent Claims:see list of patent claims

Details for Patent 9,994,615

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Eli Lilly And Company HUMALOG insulin lispro Injection 020563 06/14/1996 ⤷  Try a Trial 2032-02-17
Eli Lilly And Company HUMALOG insulin lispro Injection 020563 08/06/1998 ⤷  Try a Trial 2032-02-17
Eli Lilly And Company HUMALOG insulin lispro Injection 020563 09/06/2007 ⤷  Try a Trial 2032-02-17
Eli Lilly And Company HUMALOG insulin lispro Injection 020563 06/06/2017 ⤷  Try a Trial 2032-02-17
Eli Lilly And Company HUMALOG insulin lispro Injection 020563 11/15/2019 ⤷  Try a Trial 2032-02-17
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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