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Last Updated: September 27, 2020

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Patent: 9,987,369

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Summary for Patent: 9,987,369
Title:Vitamin functionalized gel-forming block copolymers for biomedical applications
Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *--N(H)--* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *--N(H)--* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).
Inventor(s): Cheng; Wei (Singapore, SG), Fevre; Mareva B. (San Jose, CA), Hedrick; James L. (Pleasanton, CA), Ibrahim; Nor Lizawati (Singapore, SG), Lee; Ashlynn L. Z. (Singapore, SG), Ng; Victor W. L. (Singapore, SG), Ono; Robert J. (San Jose, CA), Yang; Chuan (Singapore, SG), Yang; Yi Yan (Singapore, SG)
Assignee: International Business Machines Corporation (Armonk, NY) Agency For Science, Technology And Research (Singapore, SG)
Application Number:15/340,795
Patent Claims:see list of patent claims

Details for Patent 9,987,369

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial International Business Machines Corporation (Armonk, NY) Agency For Science, Technology And Research (Singapore, SG) 2039-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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