Patent: 9,982,032
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Summary for Patent: 9,982,032
| Title: | Stable liquid formulation of fusion protein with IgG Fc domain |
| Abstract: | A stable liquid formulation includes a fusion protein having an Fc domain of a human immunoglobulin G (IgG), in particular, a protein in which an Fc domain of a human immunoglobulin G (IgG) and a soluble extracellular domain of a vascular endothelial growth factor (VEGF) receptor are fused (e.g., aflibercept)). A composition for stabilizing a protein and a method for stabilizing a protein in which an Fc domain of an IgG and a soluble extracellular domain of a VEGF receptor are fused are disclosed. The present invention improves therapeutic effects on various ophthalmic diseases (e.g., retinal vein occlusion, diabetic macular edema, choroidal neovascularization and wet age-related macular degeneration, etc.) caused by abnormal angiogenesis, while pursuing stabilization of bioactivity through a stable liquid formulation suitable for intravitreal injection of an anti-VEGF-Fc fusion protein including aflibercept. |
| Inventor(s): | Park; Soon Jae (Daejeon, KR), Chung; Hye-Shin (Daejeon, KR), Kim; Jin Hwan (Daejeon, KR), Kim; Yong Mo (Daejeon, KR), Kim; Jun Young (Daejeon, KR) |
| Assignee: | ALTEOGEN, INC. (Daejeon, KR) |
| Application Number: | 15/190,378 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,982,032
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Csl Behring Ag | CARIMUNE, CARIMUNE NF, PANGLOBULIN, SANDOGLOBULIN | immune globulin intravenous (human) | For Injection | 102367 | 07/27/2000 | ⤷ Try a Trial | 2035-06-23 |
| Csl Behring Ag | PRIVIGEN | immune globulin intravenous (human), 10% liquid | Injection | 125201 | 07/26/2007 | ⤷ Try a Trial | 2035-06-23 |
| Csl Behring Ag | PRIVIGEN | immune globulin intravenous (human), 10% liquid | Injection | 125201 | 10/02/2009 | ⤷ Try a Trial | 2035-06-23 |
| Csl Behring Ag | PRIVIGEN | immune globulin intravenous (human), 10% liquid | Injection | 125201 | 02/07/2013 | ⤷ Try a Trial | 2035-06-23 |
| Bio Products Laboratory | GAMMAPLEX | immune globulin intravenous (human) | Injection | 125329 | 09/17/2009 | ⤷ Try a Trial | 2035-06-23 |
| Bio Products Laboratory | GAMMAPLEX | immune globulin intravenous (human) | Injection | 125329 | 02/06/2017 | ⤷ Try a Trial | 2035-06-23 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
