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Last Updated: December 3, 2021

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Patent: 9,975,937

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Summary for Patent: 9,975,937
Title:Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia
Abstract: The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with supraphysiological levels of interleukin (IL)-15. The present invention also provides methods for preventing, alleviating, reducing, and/or inhibiting lymphopenia or peripheral depletion of lymphocytes in a patient in need thereof by administering to the patient IL-15.
Inventor(s): Pavlakis; George N. (Rockville, MD), Felber; Barbara K. (Rockville, MD), Valentin; Antonio (Frederick, MD), Bergamaschi; Cristina (Frederick, MD)
Assignee: THE UNITED SSTATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Washington, DC)
Application Number:14/512,913
Patent Claims:see list of patent claims

Details for Patent 9,975,937

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genzyme Corporation CAMPATH alemtuzumab Injection 103948 2001-05-07 ⤷  Try it Free 2029-08-14
Genzyme Corporation LEMTRADA alemtuzumab Injection 103948 2014-11-14 ⤷  Try it Free 2029-08-14
Genzyme Corporation CAMPATH alemtuzumab Injection 103948 2004-10-12 ⤷  Try it Free 2029-08-14
Astellas Pharma Us, Inc. AMEVIVE alefacept For Injection 125036 2003-01-30 ⤷  Try it Free 2029-08-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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