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Last Updated: September 21, 2020

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Patent: 9,969,811

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Summary for Patent: 9,969,811
Title:Pertuzumab variants and evaluation thereof
Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.
Inventor(s): Gennaro; Lynn A. (San Mateo, CA), Kao; Yung-Hsiang (San Mateo, CA), Zhang; Yonghua (Foster City, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:15/788,574
Patent Claims:see list of patent claims

Details for Patent 9,969,811

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08   Start Trial Genentech, Inc. (South San Francisco, CA) 2033-04-16 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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