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Last Updated: March 29, 2024

Patent: 9,964,545


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Summary for Patent: 9,964,545
Title:Methods for quantifying polypeptides using mass spectrometry
Abstract: A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of including an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent including an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent including an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole.
Inventor(s): Chambers; Erin E. (North Brookfield, MA), Stapels; Martha (Bellingham, MA), Mather; Joanne (Millis, MA)
Assignee: WATERS TECHNOLOGIES CORPORATION (Milford, MA)
Application Number:15/447,838
Patent Claims:see list of patent claims

Details for Patent 9,964,545

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Novo Nordisk Inc. NOVOLOG insulin aspart Injection 020986 06/07/2000 ⤷  Try a Trial 2032-04-18
Novo Nordisk Inc. NOVOLOG insulin aspart Injection 020986 01/19/2001 ⤷  Try a Trial 2032-04-18
Novo Nordisk Inc. NOVOLOG insulin aspart Injection 020986 04/23/2004 ⤷  Try a Trial 2032-04-18
Novo Nordisk Inc. NOVOLOG insulin aspart Injection 020986 10/31/2013 ⤷  Try a Trial 2032-04-18
Sanofi-aventis U.s. Llc LANTUS insulin glargine Injection 021081 04/20/2000 ⤷  Try a Trial 2032-04-18
Sanofi-aventis U.s. Llc LANTUS insulin glargine Injection 021081 04/25/2007 ⤷  Try a Trial 2032-04-18
Novo Nordisk Inc. LEVEMIR insulin detemir Injection 021536 06/16/2005 ⤷  Try a Trial 2032-04-18
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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