Patent: 9,949,971

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Summary for Patent: 9,949,971

Title:	Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor
Abstract:	Therapeutic combinations of a Janus kinase-2 (JAK-2) inhibitor, a Bruton\'s tyrosine kinase (BTK) inhibitor, and/or a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the .gamma.- and .delta.-isoforms and selective for both .gamma.- and .delta.-isoforms, are described. In some embodiments, the invention provides pharmaceutical compositions comprising combinations of (1) a PI3K-.delta. inhibitor and a BTK inhibitor, (2) a JAK-2 inhibitor and a BTK inhibitor, or (3) a JAK-2 inhibitor, PI3K-.delta. inhibitor, and BTK inhibitor, and methods of using the pharmaceutical compositions for treating a disease, in particular a cancer.
Inventor(s):	Hamdy; Ahmed (Santa Cruz, CA), Rothbaum; Wayne (Delray Beach, FL), Izumi; Raquel (San Carlos, CA), Lannutti; Brian (Solana Beach, CA), Covey; Todd (San Carlos, CA), Ulrich; Roger (Sammamish, WA), Johnson; Dave (Aptos, CA), Barf; Tjeerd (Ravenstein, NL), Kaptein; Allard (Zaltbommel, NL)
Assignee:	Acerta Pharma B.V. (Oss, NL)
Application Number:	15/319,740
Patent Claims:	see list of patent claims

Details for Patent 9,949,971

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Genentech	RITUXAN	rituximab	VIAL	103705	001	1997-11-26	➤ Sign Up	Acerta Pharma B.V. (Oss, NL)	2034-06-17	RX		search
Glaxo Grp Ltd	ARZERRA	ofatumumab	INJECTABLE; INJECTION	125326	001	2009-10-26	➤ Sign Up	Acerta Pharma B.V. (Oss, NL)	2034-06-17	RX		search
Genentech	GAZYVA	obinutuzumab	INJECTABLE;INJECTION	125486	001	2013-11-01	➤ Sign Up	Acerta Pharma B.V. (Oss, NL)	2034-06-17	RX	Orphan	search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 9,949,971

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Country	Patent Number	Publication Date
Argentina	100891	Nov 09, 2016
Taiwan	201613644	Apr 16, 2016
United States of America	2017136014	May 18, 2017
>Country	>Patent Number	>Publication Date

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