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Last Updated: July 5, 2020

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Patent: 9,944,898

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Summary for Patent: 9,944,898
Title:Method of generating tumor-specific T cells
Abstract: A method for the expansion of tumor-specific T-cells includes obtaining an enriched population of T-cells from a subject with cancer; and contacting the enriched population of T-cells ex-vivo with: (i) an anti-CD3 antibody, an anti-CD28 antibody, and/or functional fragments thereof, and (ii) a VEGF inhibitor, to activate and expand the T-cells.
Inventor(s): Kim; Julian (Cleveland, OH), Graor; Hallie (Cleveland, OH), Zhang; Mei (Cleveland, OH), Visioni; Anthony (Cleveland, OH)
Assignee: Case Western Reserve University (Cleveland, OH)
Application Number:14/205,069
Patent Claims:see list of patent claims

Details for Patent 9,944,898

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26   Start Trial Case Western Reserve University (Cleveland, OH) 2033-03-11 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Start Trial Case Western Reserve University (Cleveland, OH) 2033-03-11 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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