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Generated: September 16, 2019

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Patent: 9,938,356

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Summary for Patent: 9,938,356
Title:Binding molecules specific for CD73 and uses thereof
Abstract: The present disclosure provides anti-CD73 binding molecules, e.g., antibodies and antigen binding fragments thereof. Also provided are pharmaceutical formulations comprising the disclosed compositions, and methods for the diagnosis and treatment of diseases associated with CD73-expression, e.g., cancer. Such diseases can be treated, e.g., by direct therapy with the anti-CD73 binding molecules disclosed herein (e.g., naked antibodies or antibody-drug conjugates that bind CD73), by adjuvant therapy with other antigen-binding anticancer agents such as immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1 monoclonal antibodies), and/or by combination therapies where the anti-CD73 molecules are administered before, after, or concurrently with chemotherapy.
Inventor(s): Hay; Carl (Gaithersburg, MD), Sachsenmeier; Kris (Gaithersbrug, MD), Sult; Erin (Gaithersburg, MD), Huang; Qihui (Gaithersburg, MD), Pavlik; Peter (Gaithersburg, MD), Damschroder; Melissa (Gaithersburg, MD), Cheng; Li (Gaithersburg, MD), Diedrich; Gundo (Gaithersburg, MD), Rios-Doria; Jonathan (Gaithersburg, MD), Hammond; Scott (Gaithersburg, MD), Minter; Ralph (Cambridge, GB), Rust; Steve (Cambridge, GB), Guillard; Sandrine (Cambridge, GB), Hollingsworth; Robert (Gaithersburg, MD), Jermutus; Lutz (Cambridge, GB), Durham; Nicholas (Gaithersburg, MD), Leow; Ching Ching (Gaithersburg, MD), Antonysamy; Mary (Gaithersburg, MD), Geoghegan; James (Gaithersburg, MD), Lu; Xiaojun (Gaithersburg, MD), Rosenthal; Kim (Gaithersburg, MD)
Assignee: MEDIMMUNE LIMITED (Cambridge, GB)
Application Number:14/936,233
Patent Claims:see list of patent claims

Details for Patent 9,938,356

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bristol Myers Squibb YERVOY ipilimumab INJECTABLE; INJECTION 125377 001 2011-03-25   Try a Free Trial 2038-10-17 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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