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Last Updated: July 3, 2020

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Patent: 9,931,417

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Summary for Patent: 9,931,417
Title:Antibody-SN-38 immunoconjugates with a CL2A linker
Abstract: The present invention concerns improved methods and compositions for preparing SN-38 conjugates of proteins or peptides, preferably immunoconjugates of antibodies or antigen-binding antibody fragments. More preferably, the SN-38 is attached to the antibody or antibody fragment using a CL2A linker, with 1-12, more preferably 6-8, alternatively 1-5 SN-38 moieties per antibody or antibody fragment. Most preferably, the immunoconjugate is prepared in large scale batches, with various modifications to the reaction scheme disclosed herein to optimize yield and recovery in large scale. Other embodiments concern optimized dosages and/or schedules of administration of immunoconjugate to maximize efficacy for disease treatment and minimize side effects of administration.
Inventor(s): Govindan; Serengulam V. (Summit, NJ), Gale; Jonathan B. (West Townsend, MA), Holman; Nicholas J. (Leominster, MA), Goldenberg; David M. (Mendham, NJ)
Assignee: Immunomedics, Inc. (Morris Plains, NJ)
Application Number:15/196,586
Patent Claims:see list of patent claims

Details for Patent 9,931,417

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Fresenius Kabi Usa CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017067 004 1973-03-05   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 RX search
Fresenius Kabi Usa CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017067 003 1973-03-05   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 RX search
Fresenius Kabi Usa CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017067 002 1973-03-05   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 RX search
Fresenius Kabi Usa CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017067 001 1973-03-05   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 RX search
Bel Mar CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017054 002 1974-03-26   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 DISCN search
Bel Mar CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017054 001 1974-03-26   Start Trial Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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