Patent: 9,931,417
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Summary for Patent: 9,931,417
Title: | Antibody-SN-38 immunoconjugates with a CL2A linker |
Abstract: | The present invention concerns improved methods and compositions for preparing SN-38 conjugates of proteins or peptides, preferably immunoconjugates of antibodies or antigen-binding antibody fragments. More preferably, the SN-38 is attached to the antibody or antibody fragment using a CL2A linker, with 1-12, more preferably 6-8, alternatively 1-5 SN-38 moieties per antibody or antibody fragment. Most preferably, the immunoconjugate is prepared in large scale batches, with various modifications to the reaction scheme disclosed herein to optimize yield and recovery in large scale. Other embodiments concern optimized dosages and/or schedules of administration of immunoconjugate to maximize efficacy for disease treatment and minimize side effects of administration. |
Inventor(s): | Govindan; Serengulam V. (Summit, NJ), Gale; Jonathan B. (West Townsend, MA), Holman; Nicholas J. (Leominster, MA), Goldenberg; David M. (Mendham, NJ) |
Assignee: | Immunomedics, Inc. (Morris Plains, NJ) |
Application Number: | 15/196,586 |
Patent Claims: | see list of patent claims |
Details for Patent 9,931,417
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Ferring Pharmaceuticals Inc. | NOVAREL | chorionic gonadotropin | For Injection | 017016 | 01/15/1974 | ⤷ Try a Trial | 2032-12-13 |
Ferring Pharmaceuticals Inc. | NOVAREL | chorionic gonadotropin | For Injection | 017016 | 12/27/1984 | ⤷ Try a Trial | 2032-12-13 |
Ferring Pharmaceuticals Inc. | NOVAREL | chorionic gonadotropin | For Injection | 017016 | 02/15/1985 | ⤷ Try a Trial | 2032-12-13 |
Ferring Pharmaceuticals Inc. | NOVAREL | chorionic gonadotropin | For Injection | 017016 | 02/16/1990 | ⤷ Try a Trial | 2032-12-13 |
Bel-mar Laboratories, Inc. | CHORIONIC GONADOTROPIN | chorionic gonadotropin | Injection | 017054 | 03/26/1974 | ⤷ Try a Trial | 2032-12-13 |
Fresenius Kabi Usa, Llc | CHORIONIC GONADOTROPIN | chorionic gonadotropin | For Injection | 017067 | 03/05/1973 | ⤷ Try a Trial | 2032-12-13 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |