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Last Updated: February 18, 2020

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Patent: 9,925,310

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Summary for Patent: 9,925,310
Title:Biocompatible and bioabsorbable derivatized chitosan compositions
Abstract: The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.
Inventor(s): McGrath; Barbara (Portland, OR), McCarthy; Simon (Portland, OR), Kuhn; Sam (Portland, OR), Wold; Alysha (Portland, OR), Stolten; Michael (Portland, OR), Bennett; Amanda (Portland, OR)
Assignee: Tricol Biomedical, Inc. (Portland, OR)
Application Number:15/371,010
Patent Claims:see list of patent claims

Details for Patent 9,925,310

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bristol Myers Squibb YERVOY ipilimumab INJECTABLE; INJECTION 125377 001 2011-03-25   Start Trial Tricol Biomedical, Inc. (Portland, OR) 2033-03-14 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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