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Last Updated: February 19, 2020

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Patent: 9,920,311

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Summary for Patent: 9,920,311
Title:PEGylated L-asparaginase
Abstract: Disclosed is a conjugate of a protein having substantial L-asparagine aminohydrolase activity and polyethylene glycol. In particular, the polyethylene glycol has a molecular weight less than or equal to about 5000 Da and the protein is an L-asparaginase from Erwinia. The conjugate of the invention has shown superior properties such as maintenance of a high level of in vitro activity and an unexpected increase in half-life in vivo. Also disclosed are methods of producing the conjugate and use of the conjugate in therapy. In particular, a method is disclosed for use of the conjugate in the treatment of cancer, particularly Acute Lymphoblastic Leukemia (ALL). More specifically, a method is disclosed for use of the conjugate as a second line therapy for patients who have developed hypersensitivity or have had a disease relapse after treatment with other L-asparaginase preparations.
Inventor(s): Abribat; Thierry (Sainte Foy les Lyon, FR)
Assignee: Jazz Pharmaceuticals II SAS (Lyons, FR)
Application Number:14/819,305
Patent Claims:see list of patent claims

Details for Patent 9,920,311

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Jazz Pharmaceuticals II SAS (Lyons, FR) 2030-03-30 RX search
Jazz Pharms Inc ERWINAZE asparaginase erwinia chrysanthemi INJECTABLE; INJECTION 125359 001 2011-11-18   Start Trial Jazz Pharmaceuticals II SAS (Lyons, FR) 2030-03-30 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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