Patent: 9,920,311

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Summary for Patent: 9,920,311

Title:	PEGylated L-asparaginase
Abstract:	Disclosed is a conjugate of a protein having substantial L-asparagine aminohydrolase activity and polyethylene glycol. In particular, the polyethylene glycol has a molecular weight less than or equal to about 5000 Da and the protein is an L-asparaginase from Erwinia. The conjugate of the invention has shown superior properties such as maintenance of a high level of in vitro activity and an unexpected increase in half-life in vivo. Also disclosed are methods of producing the conjugate and use of the conjugate in therapy. In particular, a method is disclosed for use of the conjugate in the treatment of cancer, particularly Acute Lymphoblastic Leukemia (ALL). More specifically, a method is disclosed for use of the conjugate as a second line therapy for patients who have developed hypersensitivity or have had a disease relapse after treatment with other L-asparaginase preparations.
Inventor(s):	Abribat; Thierry (Sainte Foy les Lyon, FR)
Assignee:	Jazz Pharmaceuticals II SAS (Lyons, FR)
Application Number:	14/819,305
Patent Claims:	see list of patent claims

Details for Patent 9,920,311

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Merck	ELSPAR	asparaginase	VIAL	101063	001	1978-01-10	Try a Free Trial	Jazz Pharmaceuticals II SAS (Lyons, FR)	2030-03-30	RX		search
Jazz Pharms Inc	ERWINAZE	asparaginase erwinia chrysanthemi	INJECTABLE; INJECTION	125359	001	2011-11-18	Try a Free Trial	Jazz Pharmaceuticals II SAS (Lyons, FR)	2030-03-30	RX	Orphan	search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

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