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Last Updated: July 11, 2020

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Patent: 9,896,678

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Summary for Patent: 9,896,678
Title:Mutant with enhanced secretion of L-asparaginase and its application
Abstract: The present invention provides a mutant with enhanced secretion of L-asparaginase and its application, which relates to the field of enzyme engineering. This invention successfully constructed a mutant with enhanced secretion of L-asparaginase through N-terminal deletion on amino acid sequence of L-asparaginase, and then expressed the mutant via a recombinant strain. Compared with the wild L-asparaginase, the secretion ability of L-asparaginase mutant in present invention significantly improves by 3.14 times compared to that of wild type. The recombinant strain that constructed in this prevention has an L-asparaginase yield of 407.6 U/mL and a production efficiency of 9.26 U/(mL/h), which reaches to the highest yield been reported.
Inventor(s): Liu; Song (Wuxi, CN), Feng; Yue (Wuxi, CN), Chen; Jian (Wuxi, CN), Du; Guocheng (Wuxi, CN), Jiao; Yun (Wuxi, CN), Ruan; Jie (Wuxi, CN), Cheng; Hongye (Wuxi, CN), Gao; Hui (Wuxi, CN)
Assignee: Jiangnan University (Wuxi, Jiangsu, CN)
Application Number:15/189,139
Patent Claims:see list of patent claims

Details for Patent 9,896,678

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Jiangnan University (Wuxi, Jiangsu, CN) 2035-11-25 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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