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Last Updated: November 29, 2021

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Patent: 9,896,678

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Summary for Patent: 9,896,678
Title:Mutant with enhanced secretion of L-asparaginase and its application
Abstract: The present invention provides a mutant with enhanced secretion of L-asparaginase and its application, which relates to the field of enzyme engineering. This invention successfully constructed a mutant with enhanced secretion of L-asparaginase through N-terminal deletion on amino acid sequence of L-asparaginase, and then expressed the mutant via a recombinant strain. Compared with the wild L-asparaginase, the secretion ability of L-asparaginase mutant in present invention significantly improves by 3.14 times compared to that of wild type. The recombinant strain that constructed in this prevention has an L-asparaginase yield of 407.6 U/mL and a production efficiency of 9.26 U/(mL/h), which reaches to the highest yield been reported.
Inventor(s): Liu; Song (Wuxi, CN), Feng; Yue (Wuxi, CN), Chen; Jian (Wuxi, CN), Du; Guocheng (Wuxi, CN), Jiao; Yun (Wuxi, CN), Ruan; Jie (Wuxi, CN), Cheng; Hongye (Wuxi, CN), Gao; Hui (Wuxi, CN)
Assignee: Jiangnan University (Wuxi, Jiangsu, CN)
Application Number:15/189,139
Patent Claims:see list of patent claims

Details for Patent 9,896,678

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 1978-01-10 ⤷  Try it Free 2035-11-25
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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