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Generated: August 24, 2019

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Patent: 9,890,189

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Summary for Patent: 9,890,189
Title:Gemcitabine prodrugs and uses thereof
Abstract: The present invention provides compounds according to formula I: ##STR00001## and pharmaceutically acceptable salts thereof. For compounds of formula I, R.sup.1 and R.sup.2 are independently selected from the group consisting of H, --C(.dbd.O)--(CH.sub.2).sub.2-aryl, and --C(.dbd.O)--(CH.sub.2).sub.n--C(.dbd.O)--NH-aryl. The subscript n is from 2 to 6. R.sup.3 is selected from the group consisting of H and --C(.dbd.O)--O--R.sup.4; and R.sup.4 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, arylalkyl, substituted arylalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl and substituted heteroalkyl. Compounds are provided wherein at least one of R.sup.1 and R.sup.2 is other than H. Pharmaceutical compositions, methods for inhibiting the growth of cancer cells, and methods for the treatment of cancer are also provided.
Inventor(s): Wu; Laurence I. (Taipei, TW)
Assignee: BoYen Therapeutics, Inc. (Taipei, TW)
Application Number:15/369,187
Patent Claims:see list of patent claims

Details for Patent 9,890,189

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18 ➤ Sign Up BoYen Therapeutics, Inc. (Taipei, TW) 2032-11-13 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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International Patent Family for US Patent 9,890,189

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2014078295 May 21, 2015
World Intellectual Property Organization (WIPO) 2014078295 May 22, 2014
United States of America 2014134160 May 15, 2014
United States of America 2015132298 May 14, 2015
United States of America 2017107245 Apr 20, 2017
United States of America 8956613 Feb 17, 2015
United States of America 9540410 Jan 10, 2017
>Country >Patent Number >Publication Date

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