Patent: 9,889,205
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Summary for Patent: 9,889,205
| Title: | Glucose-responsive insulin conjugates |
| Abstract: | Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A. |
| Inventor(s): | Lin; Songnian (Monroe, NJ), Yan; Lin (East Brunswick, NJ), Huo; Pei (Millburn, NJ) |
| Assignee: | Merck Sharp & Dohme Corp. (Rahway, NJ) |
| Application Number: | 15/191,584 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,889,205
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Eli Lilly And Company | HUMULIN R U-100 | insulin human | Injection | 018780 | 10/28/1982 | ⤷ Try a Trial | 2033-10-04 |
| Eli Lilly And Company | HUMULIN R U-500 | insulin human | Injection | 018780 | 12/29/2015 | ⤷ Try a Trial | 2033-10-04 |
| Eli Lilly And Company | HUMULIN R U-100 | insulin human | Injection | 018780 | 08/06/1998 | ⤷ Try a Trial | 2033-10-04 |
| Eli Lilly And Company | HUMULIN R U-500 | insulin human | Injection | 018780 | 03/31/1994 | ⤷ Try a Trial | 2033-10-04 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
