Make Better Decisions - Finding and Evaluating Generic and Branded Drug Market Entry Opportunities

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Generated: July 19, 2019

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Patent: 9,879,077

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Summary for Patent: 9,879,077
Title:Anti-serum albumin Fab-effector moiety fusion construct, and a method of preparing the construct
Abstract: The present invention relates to antigen-binding fragment (Fab) and a Fab-effector fusion protein or (poly)peptide comprising thereof. The Fab of the present invention specifically binds to serum albumin and thereby has extended in vivo half-life. The Fab of the present invention is characterized by not having cysteine residues that are responsible for the interchain disulfide bond in C.sub.H1 domain and C.sub..kappa.L domain as well. The Fab-effector fusion protein or (poly)peptide of the present invention can be produced in periplasm of E. coli with high yield, and has increased in vivo half-life. Further, the present invention provides E. coli strain which produces various kinds of Fab-effector fusion proteins or (poly)peptides, and a pharmaceutical composition comprising the fab-effector fusion proteins or (poly)peptides.
Inventor(s): Cha; Sanghoon (Gangwon-Do, KR)
Assignee: AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR)
Application Number:15/056,299
Patent Claims:see list of patent claims

Details for Patent 9,879,077

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ➤ Sign Up AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR) ➤ Sign Up RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Sign Up AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR) ➤ Sign Up RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Sign Up AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR) ➤ Sign Up RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ➤ Sign Up AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR) ➤ Sign Up RX Orphan search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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Serving hundreds of leading biopharmaceutical companies globally:

Baxter
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Chinese Patent Office

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