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Last Updated: February 18, 2020

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Patent: 9,879,077

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Summary for Patent: 9,879,077
Title:Anti-serum albumin Fab-effector moiety fusion construct, and a method of preparing the construct
Abstract: The present invention relates to antigen-binding fragment (Fab) and a Fab-effector fusion protein or (poly)peptide comprising thereof. The Fab of the present invention specifically binds to serum albumin and thereby has extended in vivo half-life. The Fab of the present invention is characterized by not having cysteine residues that are responsible for the interchain disulfide bond in C.sub.H1 domain and C.sub..kappa.L domain as well. The Fab-effector fusion protein or (poly)peptide of the present invention can be produced in periplasm of E. coli with high yield, and has increased in vivo half-life. Further, the present invention provides E. coli strain which produces various kinds of Fab-effector fusion proteins or (poly)peptides, and a pharmaceutical composition comprising the fab-effector fusion proteins or (poly)peptides.
Inventor(s): Cha; Sanghoon (Gangwon-Do, KR)
Assignee: AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR)
Application Number:15/056,299
Patent Claims:see list of patent claims

Details for Patent 9,879,077

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR) 2033-08-30 RX search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR) 2033-08-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR) 2033-08-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR) 2033-08-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial AprilBio Co., Ltd. (Chuncheon, Gangwon-do, KR) 2033-08-30 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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