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Generated: September 17, 2019

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Patent: 9,868,972

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Summary for Patent: 9,868,972

Title:	Hybrid suppressor tRNA for vertebrate cells
Abstract:	This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA\'s, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA\'s/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA\'s (O-tRNA\'s) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
Inventor(s):	Tian; Feng (San Diego, CA), Norman; Thea (Clinton, WA), Chu; Stephanie (Simi Valley, CA)
Assignee:	Ambrx,Inc. (La Jolla, CA)
Application Number:	14/820,318
Patent Claims:	see list of patent claims

Details for Patent 9,868,972

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	001	2015-01-23	➤ Sign Up	Ambrx,Inc. (La Jolla, CA)	2026-09-08	RX	Orphan	search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	002	2015-01-23	➤ Sign Up	Ambrx,Inc. (La Jolla, CA)	2026-09-08	RX	Orphan	search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	003	2015-01-23	➤ Sign Up	Ambrx,Inc. (La Jolla, CA)	2026-09-08	RX	Orphan	search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	004	2015-01-23	➤ Sign Up	Ambrx,Inc. (La Jolla, CA)	2026-09-08	RX	Orphan	search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 9,868,972

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Country	Patent Number	Publication Date
Australia	2007292892	Aug 02, 2012
Australia	2007292892	Feb 28, 2013
Australia	2007292892	Mar 13, 2008
Canada	2662753	Feb 23, 2016
Canada	2662753	Mar 13, 2008
China	101541955	Sep 23, 2009
>Country	>Patent Number	>Publication Date

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