Patent: 9,868,972

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Summary for Patent: 9,868,972

Title:	Hybrid suppressor tRNA for vertebrate cells
Abstract:	This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA\'s, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA\'s/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA\'s (O-tRNA\'s) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
Inventor(s):	Tian; Feng (San Diego, CA), Norman; Thea (Clinton, WA), Chu; Stephanie (Simi Valley, CA)
Assignee:	Ambrx,Inc. (La Jolla, CA)
Application Number:	14/820,318
Patent Claims:	see list of patent claims

Details for Patent 9,868,972

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	10/28/1982	See Plans and Pricing	2026-09-08
Eli Lilly And Company	HUMULIN R U-500	insulin human	Injection	018780	12/29/2015	See Plans and Pricing	2026-09-08
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	08/06/1998	See Plans and Pricing	2026-09-08
Eli Lilly And Company	HUMULIN R U-500	insulin human	Injection	018780	03/31/1994	See Plans and Pricing	2026-09-08
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	05/25/2018	See Plans and Pricing	2026-09-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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