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Patent: 9,868,972
Summary for Patent: 9,868,972
| Title: | Hybrid suppressor tRNA for vertebrate cells |
| Abstract: | This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA\'s, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA\'s/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA\'s (O-tRNA\'s) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell. |
| Inventor(s): | Tian; Feng (San Diego, CA), Norman; Thea (Clinton, WA), Chu; Stephanie (Simi Valley, CA) |
| Assignee: | Ambrx,Inc. (La Jolla, CA) |
| Application Number: | 14/820,318 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,868,972
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 004 | 2015-01-23 | Start Trial | Ambrx,Inc. (La Jolla, CA) | 2026-09-08 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 003 | 2015-01-23 | Start Trial | Ambrx,Inc. (La Jolla, CA) | 2026-09-08 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 002 | 2015-01-23 | Start Trial | Ambrx,Inc. (La Jolla, CA) | 2026-09-08 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 001 | 2015-01-23 | Start Trial | Ambrx,Inc. (La Jolla, CA) | 2026-09-08 | RX | Orphan | search |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 9,868,972
| Country | Patent Number | Publication Date |
|---|---|---|
| World Intellectual Property Organization (WIPO) | 2008030613 | Mar 13, 2008 |
| World Intellectual Property Organization (WIPO) | 2008030613 | Nov 20, 2008 |
| United States of America | 2010159586 | Jun 24, 2010 |
| United States of America | 2017096696 | Apr 06, 2017 |
| United States of America | 9133495 | Sep 15, 2015 |
| Singapore | 174781 | Oct 28, 2011 |
| Portugal | 2061878 | Apr 22, 2014 |
| >Country | >Patent Number | >Publication Date |
