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Generated: July 23, 2019

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Patent: 9,867,805

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Summary for Patent: 9,867,805
Title:Gelatinase inhibitors and prodrugs
Abstract: The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be selective inhibition, for example, selective inhibition of MMP-2, MMP-9, and/or MMP-14. Thus, the invention provides non-mutagenic prodrug compounds of the formulas described herein that result in the inhibition of MMPs upon in vivo administration.
Inventor(s): Chang; Mayland (Granger, IN), Mobashery; Shahriar (Granger, IN), Lee; Mijoon (Mishawaka, IN)
Assignee: University of Notre Dame du Lac (South Bend, IN)
Application Number:15/139,055
Patent Claims:see list of patent claims

Details for Patent 9,867,805

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Sign Up University of Notre Dame du Lac (South Bend, IN) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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