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Generated: September 18, 2019

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Patent: 9,856,480

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Summary for Patent: 9,856,480
Title:Dnazyme for silencing the expression of EGFR
Abstract: The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lung cancer patients.
Inventor(s): Yang; Pan-Chyr (Taipei, TW), Lai; Wei-Yun (Taipei, TW), Peck; Konan (Taipei, TW), Chang; Cheng-Ju (Taipei, TW), Chen; Chi-Yuan (Taipei, TW), Yang; Shuenn-Chen (Taipei, TW)
Assignee: National Taiwan University (Taipei, TW) ACADEMIA SINICA (Taipei, TW)
Application Number:14/760,904
Patent Claims:see list of patent claims

Details for Patent 9,856,480

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Try a Free Trial National Taiwan University (Taipei, TW) ACADEMIA SINICA (Taipei, TW) 2038-10-10 RX Orphan search
Amgen VECTIBIX panitumumab INJECTABLE; IV (INFUSION) 125147 001 2006-09-27   Try a Free Trial National Taiwan University (Taipei, TW) ACADEMIA SINICA (Taipei, TW) 2038-10-10 RX search
Amgen VECTIBIX panitumumab INJECTABLE; IV (INFUSION) 125147 002 2006-09-27   Try a Free Trial National Taiwan University (Taipei, TW) ACADEMIA SINICA (Taipei, TW) 2038-10-10 RX search
Amgen VECTIBIX panitumumab INJECTABLE; IV (INFUSION) 125147 003 2006-09-27   Try a Free Trial National Taiwan University (Taipei, TW) ACADEMIA SINICA (Taipei, TW) 2038-10-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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