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Generated: August 22, 2019

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Patent: 9,855,344

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Summary for Patent: 9,855,344
Title:Antibody-SN-38 immunoconjugates with a CL2A linker
Abstract: The present invention concerns improved methods and compositions for preparing SN-38 conjugates of proteins or peptides, preferably immunoconjugates of antibodies or antigen-binding antibody fragments. More preferably, the SN-38 is attached to the antibody or antibody fragment using a CL2A linker, with 1-12, more preferably 6 or less, most preferably 1-5 SN-38 moieties per antibody or antibody fragment. Most preferably, the immunoconjugate is prepared in large scale batches, with various modifications to the reaction scheme to optimize yield and recovery in large scale. Other embodiments concern optimized dosages and/or schedules of administration of immunoconjugate to maximize efficacy for disease treatment and minimize side effects of administration.
Inventor(s): Govindan; Serengulam V. (Summit, NJ), Gale; Jonathan B. (West Townsend, MA), Holman; Nicholas J. (Leominster, MA), Goldenberg; David M. (Mendham, NJ)
Assignee: Immunomedics, Inc. (Morris Plains, NJ)
Application Number:15/441,653
Patent Claims:see list of patent claims

Details for Patent 9,855,344

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech GAZYVA obinutuzumab INJECTABLE;INJECTION 125486 001 2013-11-01 ➤ Sign Up Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 RX Orphan search
Genzyme LEMTRADA alemtuzumab INJECTABLE;INJECTION 103948 003 2001-05-07 ➤ Sign Up Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 002 2001-05-07 ➤ Sign Up Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07 ➤ Sign Up Immunomedics, Inc. (Morris Plains, NJ) 2032-12-13 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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