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Generated: July 22, 2019

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Patent: 9,815,904

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Summary for Patent: 9,815,904
Title:Pertuzumab variants and evaluation thereof
Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.
Inventor(s): Gennaro; Lynn A. (San Mateo, CA), Kao; Yung-Hsiang (San Mateo, CA), Zhang; Yonghua (Foster City, CA)
Assignee: Genetech, Inc. (South San Francisco, CA)
Application Number:14/253,038
Patent Claims:see list of patent claims

Details for Patent 9,815,904

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08 ➤ Try a Free Trial Genetech, Inc. (South San Francisco, CA) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 9,815,904

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2014172371 Jan 08, 2015
World Intellectual Property Organization (WIPO) 2014172371 Oct 23, 2014
United States of America 2014308277 Oct 16, 2014
United States of America 2018037660 Feb 08, 2018
United States of America 2018037661 Feb 08, 2018
United States of America 2018037662 Feb 08, 2018
Country Patent Number Publication Date

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