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Last Updated: September 30, 2020

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Patent: 9,807,986

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Summary for Patent: 9,807,986
Title:Methods for establishing animal model of hepatocellular carcinoma bone metastasis
Abstract: A method for establishing an animal model of hepatocellular carcinoma (HCC) bone metastasis, the method including: 1) establishing 97H and LM3 cell clones with stable expression of firefly luciferase (LUC); 2) allowing HCC cells to form bone metastasis in nude mice via intratibial injection; 3) reproducing HCC bone metastasis in nude mice via intracardiac injection of tumor cells; and 4) isolating a sub-population of tumor cells that targets metastasis to bone. The 97H and the LM3 are highly metastatic HCC cell lines transfected with luciferase gene. BALB/cA-nu mice are 4-5 weeks old and maintained in laminar flow cabinets under SPF conditions and received human care throughout an entire study. A cell number for intratibial injection is 0.5.times.10.sup.6, and a cell number for intracardiac injection is 1.times.10.sup.6.
Inventor(s): Hou; Rui (Wuhan, CN), Wang; Yuwei (Wuhan, CN), Liang; Huifang (Wuhan, CN), Zhang; Zhanguo (Wuhan, CN), Liu; Zhimin (Wuhan, CN), Zhang; Binhao (Wuhan, CN), Zhang; Bixiang (Wuhan, CN), Chen; Xiaoping (Wuhan, CN)
Assignee:
Application Number:15/083,269
Patent Claims:see list of patent claims

Details for Patent 9,807,986

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bausch And Lomb VITRASE hyaluronidase INJECTABLE;INJECTION 021640 001 2004-12-21   Start Trial 2039-02-26 RX search
Bausch And Lomb VITRASE hyaluronidase INJECTABLE;INJECTION 021640 002 2004-12-21   Start Trial 2039-02-26 RX search
Amphastar Pharm AMPHADASE hyaluronidase INJECTABLE;INJECTION 021665 001 2005-11-03   Start Trial 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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