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Last Updated: November 27, 2021

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Patent: 9,796,754

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Summary for Patent: 9,796,754
Title:Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
Abstract: Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
Inventor(s): Miao; Zhenwei (San Diego, CA), Atkinson; Kyle (Golden, CO), Biroc; Sandra (Alameda, CA), Buss; Timothy (Carlsbad, CA), Neal; Melissa (Vista, CA), Kraynov; Vadim (San Diego, CA), Marsden; Robin (San Diego, CA), Pinkstaff; Jason (San Rafael, CA), Skidmore; Lillian (San Diego, CA), Sun; Ying (San Diego, CA), Szydlik; Agnieszka (San Francisco, CA), Lopez De Valenta; Delia Ianina (Poway, CA)
Assignee: Ambrx, Inc. (La Jolla, CA)
Application Number:14/122,672
Patent Claims:see list of patent claims

Details for Patent 9,796,754

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Try it Free 2031-05-27
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Try it Free 2031-05-27
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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