The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
Dai; Yong (Newton, MA), Wang; Yong (North Attleboro, MA), Jin; Shengjin (Acton, MA), Meshulam; Deborah H. (Brookline, MA), Amphlett; Godfrey W. (Cambridge, MA)
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