Patent: 9,775,915
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Summary for Patent: 9,775,915
Title: | Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof |
Abstract: | Provided herein are trioxacarcin-antibody drug conjugates of Formula (A): and pharmaceutically acceptable salts thereof, comprising at least one instance of the group -L.sup.1-(A-L.sup.2)a-B attached thereto, wherein a is an integer between 1 and 10, inclusive, L.sup.1 is absent or is a linking group, A is a moiety formed from the reaction of two complimentary groups (X and Y), L.sup.2 is absent or is another linking group, and B is an antibody or antibody fragment. Also provided are methods of preparing these antibody-drug conjugates, pharmaceutically acceptable compositions thereof, and methods of their use and treatment. Further provided are precursors to the trioxacarcin-antibody drug conjugates, novel trioxacarcins without an antibody conjugated thereto, pharmaceutical compositions thereof, and methods of their use and treatment. ##STR00001## |
Inventor(s): | Myers; Andrew G. (Boston, MA), Smaltz; Daniel J. (Cambridge, MA), Schumacher; Andreas (Bottmingen, CH) |
Assignee: | President and Fellows of Harvard College (Cambridge, MA) |
Application Number: | 14/647,198 |
Patent Claims: | see list of patent claims |
Details for Patent 9,775,915
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genentech, Inc. | RITUXAN | rituximab | Injection | 103705 | 11/26/1997 | ⤷ Try a Trial | 2032-11-26 |
Idec Pharmaceuticals Corp. | RITUXAN | rituximab | Injection | 103737 | 02/19/2002 | ⤷ Try a Trial | 2032-11-26 |
Genentech, Inc. | HERCEPTIN | trastuzumab | For Injection | 103792 | 09/25/1998 | ⤷ Try a Trial | 2032-11-26 |
Genentech, Inc. | HERCEPTIN | trastuzumab | For Injection | 103792 | 02/10/2017 | ⤷ Try a Trial | 2032-11-26 |
Genzyme Corporation | CAMPATH | alemtuzumab | Injection | 103948 | 05/07/2001 | ⤷ Try a Trial | 2032-11-26 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |