Patent: 9,770,349
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Summary for Patent: 9,770,349
Title: | Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation |
Abstract: | The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or other biomedical devices having at least one dealloyed nanoporous layer that promotes improved cellular adhesion properties that promote healing and long term biocompatibility. In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression. The nanoporous layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy. |
Inventor(s): | Owens; Gary (Earlysville, VA), Lye; Whye-Kei (Charlottesville, VA), Reed; Michael (Charlottesville, VA), Spradlin; Joshua (Charlottesville, VA), Wamhoff; Brian (Charlottesville, VA), Hudson; Matthew (Charlottesville, VA), Looi; Kareen (Charlottesville, VA) |
Assignee: | University of Virginia Patent Foundation (Charlottesville, VA) |
Application Number: | 11/753,134 |
Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 9,770,349 |
Patent Claims: | see list of patent claims |
Details for Patent 9,770,349
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Microbix Biosystems Inc. | KINLYTIC | urokinase | For Injection | 021846 | 01/16/1978 | ⤷ Try a Trial | 2022-11-13 |
Genentech, Inc. | ACTIVASE | alteplase | For Injection | 103172 | 11/13/1987 | ⤷ Try a Trial | 2022-11-13 |
Genentech, Inc. | CATHFLO ACTIVASE | alteplase | For Injection | 103172 | 09/04/2001 | ⤷ Try a Trial | 2022-11-13 |
Janssen Biotech, Inc. | REOPRO | abciximab | Injection | 103575 | 12/22/1994 | ⤷ Try a Trial | 2022-11-13 |
Chiesi Usa, Inc. | RETAVASE | reteplase | For Injection | 103786 | 10/30/1996 | ⤷ Try a Trial | 2022-11-13 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |