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Last Updated: April 25, 2024

Patent: 9,770,349


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Summary for Patent: 9,770,349
Title:Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation
Abstract: The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or other biomedical devices having at least one dealloyed nanoporous layer that promotes improved cellular adhesion properties that promote healing and long term biocompatibility. In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression. The nanoporous layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy.
Inventor(s): Owens; Gary (Earlysville, VA), Lye; Whye-Kei (Charlottesville, VA), Reed; Michael (Charlottesville, VA), Spradlin; Joshua (Charlottesville, VA), Wamhoff; Brian (Charlottesville, VA), Hudson; Matthew (Charlottesville, VA), Looi; Kareen (Charlottesville, VA)
Assignee: University of Virginia Patent Foundation (Charlottesville, VA)
Application Number:11/753,134
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,770,349
Patent Claims:see list of patent claims

Details for Patent 9,770,349

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Microbix Biosystems Inc. KINLYTIC urokinase For Injection 021846 01/16/1978 ⤷  Try a Trial 2022-11-13
Genentech, Inc. ACTIVASE alteplase For Injection 103172 11/13/1987 ⤷  Try a Trial 2022-11-13
Genentech, Inc. CATHFLO ACTIVASE alteplase For Injection 103172 09/04/2001 ⤷  Try a Trial 2022-11-13
Janssen Biotech, Inc. REOPRO abciximab Injection 103575 12/22/1994 ⤷  Try a Trial 2022-11-13
Chiesi Usa, Inc. RETAVASE reteplase For Injection 103786 10/30/1996 ⤷  Try a Trial 2022-11-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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