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Last Updated: December 3, 2021

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Patent: 9,752,179

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Summary for Patent: 9,752,179
Title:Trans-splicing transcriptome profiling
Abstract: The present invention provides a method of identifying mRNA transcripts in the transcriptome of a cell comprising i) delivering into the cell a donor expression vector comprising nucleotides in a sequence encoding a trans-splicing barcode cassette, ii) exposing the cell to conditions such that the cell produces multiple copies of the trans-splicing barcode cassette encoded by the donor expression vector, which multiple copies of the trans-splicing barcode cassette each splice the barcode polynucleotide onto a mRNA transcript of the cell, thereby forming multiple mRNA transcripts of the cell, each spliced to the barcode polynucleotide; and iii) identifying the multiple mRNA transcripts that are spliced to the barcode polynucleotides, thereby identifying mRNA transcripts in the transcriptome of the cell.
Inventor(s): Zador; Anthony M. (Cold Spring Harbor, NY), Peikon; Ian D. (Cold Spring Harbor, NY), Znamenskiy; Petr (Basel, CH)
Assignee: COLD SPRING HARBOR LABORATORY (Cold Spring Harbor, NY)
Application Number:14/208,446
Patent Claims:see list of patent claims

Details for Patent 9,752,179

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2033-03-14
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2033-03-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Express Scripts
McKinsey
Colorcon
McKesson
Merck
Mallinckrodt

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