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Last Updated: December 5, 2021

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Patent: 9,738,883

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Summary for Patent: 9,738,883
Title:Process for the production and purification of the collagenase enzyme from vibrio alginolyticus
Abstract: The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacterium Vibrio alginolyticus chemovar. iophagus (NCIMB Number: 1 1038, synonym LMG 3418, hereinafter called Vibrio alginolyticus), which said process provides high production levels of collagenase with a stable, reproducible, cheap fermentation process. The collagenase produced from Vibrio alginolyticus according to the process described herein also presents a specific activity superior to that of other microbial collagenases, is stable in aqueous solution, and can be frozen without significant damage. A further subject of the present invention is pharmaceutical compositions containing collagenase obtained according to the production and purification process described, for the purpose of therapeutic treatment of disorders characterized by collagen accumulation or for the treatment of blemishes/imperfections that benefit from reducing local collagen accumulations.
Inventor(s): Vaccaro; Susanna (Abano Terme, IT), Caputo; Michele (Abano Terme, IT), Cuppari; Christian (Abano Terme, IT), Gennari; Giovanni (Abano Terme, IT)
Assignee: FIDIA FARMACEUTICALS S.P.A. (Abano Terme, IT)
Application Number:14/394,481
Patent Claims:see list of patent claims

Details for Patent 9,738,883

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 1965-06-04 ⤷  Try it Free 2032-04-18
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Baxter
Boehringer Ingelheim
Merck
McKesson
Express Scripts
AstraZeneca

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