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Last Updated: September 28, 2020

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Patent: 9,707,303

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Summary for Patent: 9,707,303
Title:Reduction stimulus-responsive gene delivery system and preparation and application thereof
Abstract: The present invention discloses a gene delivery system containing a reduction-sensitive shielding system having a targeting function, a preparation method and an application in the field of gene therapy thereof. The gene delivery system is composed of a reduction-sensitive shielding system having a targeting function, cationic polymer material and plasmid DNA; the cationic polymer material and the plasmid DNA complexed to form complex particles, the reduction-sensitive shielding system having a targeting function is shielded on the complex surface by means of electrostatic interaction, so as to reduce the toxicity of the delivery system and successfully transfer the loaded genetic material into cells, thereby achieving expression of genetic material and completing the transfection process, and moreover, improving the targeting and the efficiency of gene transfection.
Inventor(s): Gu; Zhongwei (Sichuan, CN), Nie; Yu (Sichuan, CN), He; Yiyan (Sichuan, CN), Cheng; Gang (Sichuan, CN), Xie; Li (Sichuan, CN)
Assignee: SICHUAN UNIVERSITY (Chengdu, Sichuan, CN)
Application Number:14/434,758
Patent Claims:see list of patent claims

Details for Patent 9,707,303

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial SICHUAN UNIVERSITY (Chengdu, Sichuan, CN) 2032-10-10 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial SICHUAN UNIVERSITY (Chengdu, Sichuan, CN) 2032-10-10 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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