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Last Updated: November 29, 2021

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Patent: 9,702,878

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Summary for Patent: 9,702,878
Title:Method for the prognosis and treatment of cancer metastasis
Abstract: The present invention relates to a method for the prognosis of bone metastasis in triple negative (including basal-like) breast cancer or, alternatively, ER+ breast cancer (including luminal A and B) which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering breast cancer. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of triple negative (including basal-like) breast cancer metastasis or, alternatively, ER+ breast cancer (including luminal A and B) metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering breast cancer and for classifying a subject from breast cancer into a cohort.
Inventor(s): Gomis; Roger (Barcelona, ES), Pavlovic; Milica (Lajkovac, RS), Planet; Evarist (Barcelona, ES), Arnal; Anna (Barcelona, ES), Tarragona; Maria (Barcelona, ES)
Assignee: Fundacio Institut de Recera Biomedica (IRB Barcelona) (Barcelona, ES) Institucio Catalana de Recerca I Estudis Avancats (Barcelona, ES)
Application Number:14/391,085
Patent Claims:see list of patent claims

Details for Patent 9,702,878

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Amgen, Inc. PROLIA denosumab Injection 125320 2010-06-01 ⤷  Try it Free 2032-04-09
Amgen, Inc. XGEVA denosumab Injection 125320 2010-11-18 ⤷  Try it Free 2032-04-09
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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