DrugPatentWatch Database Preview
Patent: 9,694,088
Summary for Patent: 9,694,088
| Title: | Pro-drug form (P2PDox) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer |
| Abstract: | Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2-pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments thereof (ADCs), with targetable construct peptides or with other targeting molecules that are capable of delivering the P2PDox to a targeted cell, tissue or pathogen. Once delivered to the target cell, the ADC or peptide conjugate is internalized, a highly toxic 2-pyrrolinodoxorubicin (2-PDox) is released intracellularly. The P2PDox-peptide or ADC conjugates are of use to treat a wide variety of diseases, such as cancer, autoimmune disease or infectious disease. |
| Inventor(s): | Govindan; Serengulam V. (Summit, NJ), McBride; William J. (Boonton, NJ), Sathyanarayan; Nalini (Edison, NJ), Mazza-Ferreira; Christine (Park Ridge, NJ), Goldenberg; David M. (Mendham, NJ) |
| Assignee: | Immunomedics, Inc. (Morris Plains, NJ) |
| Application Number: | 15/270,542 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,694,088
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bristol Myers Squibb | OPDIVO | nivolumab | INJECTABLE;INJECTION | 125554 | 001 | 2015-11-23 | Start Trial | Immunomedics, Inc. (Morris Plains, NJ) | 2033-02-07 | RX | Orphan | search |
| Bristol Myers Squibb | OPDIVO | nivolumab | INJECTABLE;INJECTION | 125527 | 002 | 2015-03-04 | Start Trial | Immunomedics, Inc. (Morris Plains, NJ) | 2033-02-07 | RX | search | |
| Bristol Myers Squibb | OPDIVO | nivolumab | INJECTABLE;INJECTION | 125527 | 001 | 2015-03-04 | Start Trial | Immunomedics, Inc. (Morris Plains, NJ) | 2033-02-07 | RX | search | |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 004 | 2015-01-23 | Start Trial | Immunomedics, Inc. (Morris Plains, NJ) | 2033-02-07 | RX | Orphan | search |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 9,694,088
| Country | Patent Number | Publication Date |
|---|---|---|
| World Intellectual Property Organization (WIPO) | 2014124227 | Aug 14, 2014 |
| United States of America | 2014219956 | Aug 07, 2014 |
| United States of America | 2015018516 | Jan 15, 2015 |
| United States of America | 2015283264 | Oct 08, 2015 |
| >Country | >Patent Number | >Publication Date |
