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Last Updated: July 11, 2020

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Patent: 9,693,968

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Summary for Patent: 9,693,968
Title:Cholestosome vesicles for incorporation of molecules into chylomicrons
Abstract: The present invention is directed to a cargo-loaded cholesteryl ester nanoparticle with a hollow compartment (\"cholestosome\") consisting essentially of at least one non-ionic cholesteryl ester and one or more encapsulated active molecules which cannot appreciably pass through an enterocyte membrane in the absence of said molecule being loaded into said cholestosome, the cholestosome having a neutral surface and having the ability to pass into enterocytes in the manner of orally absorbed nutrient lipids using cell pathways to reach the golgi apparatus. Pursuant to the present invention, the novel cargo loaded cholestosomes according to the present invention are capable of depositing active molecules within cells of a patient or subject and effecting therapy or diagnosis of the patient or subject.
Inventor(s): Schentag; Jerome J. (Amherst, NY), McCourt; Mary P. (Amherst, NY), Mielnicki; Lawrencee (Buffalo, NY), Hughes; Julie (Williamsville, NY)
Application Number:14/776,308
Patent Claims:see list of patent claims

Details for Patent 9,693,968

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial 2033-03-14 RX search
Mylan Pharms Inc SEMGLEE insulin glargine INJECTABLE;INJECTION 210605 001 2020-06-11   Start Trial 2033-03-14 RX search
Sanofi-aventis Us ADMELOG insulin lispro SOLUTION;INTRAVENOUS, SUBCUTANEOUS 209196 003 2018-10-19   Start Trial 2033-03-14 RX search
Sanofi-aventis Us ADMELOG SOLOSTAR insulin lispro SOLUTION;INTRAVENOUS, SUBCUTANEOUS 209196 002 2018-10-19   Start Trial 2033-03-14 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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