Patent: 9,688,965
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Summary for Patent: 9,688,965
Title: | Recombinant neuraminidase and uses thereof |
Abstract: | A recombinant neuraminidase based on amino acid sequence (SEQ ID NO: 1) of wild-type pH1N1-NA (A/Texas/05/2009) influenza virus is provided. The recombinant neuraminidase of the present invention has an ectodomain with an amino acid sequence identical to SEQ ID NO: 1 and replaced at specific positions 149, 344, 365 and 366 residue(s) with corresponding amino acids of other influenza viruses. The recombinant neuraminidase may incur cross-protective immunity and be used as universal influenza vaccine. |
Inventor(s): | Wu; Suh-Chin (Hsinchu, TW), Liu; Wen-Chun (Hsinchu, TW), Lin; Chia-Ying (Hsinchu, TW) |
Assignee: | National Tsing Hua University (Hsinchu, TW) |
Application Number: | 14/685,286 |
Patent Claims: | see list of patent claims |