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Last Updated: September 23, 2020

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Patent: 9,681,646

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Summary for Patent: 9,681,646
Title:Dosage compensating transgenes and cells
Abstract: Methods and compositions for reducing expression of genes on Chromosome 21 (\"Chr 21\") by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16.
Inventor(s): Lawrence; Jeanne B. (Mapleville, RI), Jiang; Jun (Shrewsbury, MA), Hall; Lisa L. (Framingham, MA)
Assignee: University of Massachusetts (Boston, MA)
Application Number:14/215,997
Patent Claims:see list of patent claims

Details for Patent 9,681,646

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial University of Massachusetts (Boston, MA) 2033-03-15 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial University of Massachusetts (Boston, MA) 2033-03-15 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial University of Massachusetts (Boston, MA) 2033-03-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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