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Generated: July 23, 2019

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Patent: 9,677,087

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Summary for Patent: 9,677,087
Title:Vectors and methods for long-term immune evasion to prolong tranplant viability
Abstract: A method can include making one or more compositions for altering allogeneic cells of a human donor for a human recipient by identifying at least one mismatch in an HLA protein between the human donor and the human recipient; determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding a domain having the mismatch or among domains having a plurality of mismatches; and forming at least one of the one or more compositions by constructing a virus vector for expressing a sequence targeting the consensus conserved nucleic acid sequence, which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches.
Inventor(s): Cicciarelli; James C. (Rolling Hills, CA), Kasahara; Noriyuki (Los Angeles, CA), Logg; Christopher R. (South Pasedena, CA)
Assignee: NATIONAL INSTITUTE OF TRANSPLANTATION FOUNDATION (Los Angeles, CA)
Application Number:13/567,064
Patent Claims:see list of patent claims

Details for Patent 9,677,087

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Sign Up NATIONAL INSTITUTE OF TRANSPLANTATION FOUNDATION (Los Angeles, CA) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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