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Last Updated: September 18, 2020

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Patent: 9,655,979

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Summary for Patent: 9,655,979
Title:RNA trans-splicing molecule (RTM) for use in the treatment of cancer
Abstract: The present invention pertains to a novel pre-mRNA trans-splicing molecule (RTM) comprising a binding region which is complementary to a pre mRNA of a tumor associated gene, and a coding domain which encodes for a suicide gene. Specific embodiments of the present invention relate to RTMs which mediate trans-splicing of a suicide gene, such as thymidine kinase from herpes simplex virus (HSV-tk), with the pre mRNA of the squamous cell carcinoma associated gene solute carrier organic anion transporter family member 1B3 (SLCO1B3). The invention provides RTMs which selectively kill cells expressing SLCO1B3 and which are thus useful in the treatment of cancer, specifically squamous cell carcinoma associated with epidermolysis bullosa. Also provided are methods, kits and pharmaceutical compositions relating to the RTMs in accordance to the invention.
Inventor(s): Bauer; Johann (Salzburg, AT), Gruber; Christina (Bad Vigaun, AT), Koller; Ulrich (Neumarkt am Wallersee, AT)
Assignee: Bauer; Johann (Salzburg, AT) Gruber; Christina (Bad Vigaun, AT) Koller; Ulrich (Neumarkt am Wallersee, AT)
Application Number:14/438,625
Patent Claims:see list of patent claims

Details for Patent 9,655,979

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Bauer; Johann (Salzburg, AT) Gruber; Christina (Bad Vigaun, AT) Koller; Ulrich (Neumarkt am Wallersee, AT) 2032-11-02 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Bauer; Johann (Salzburg, AT) Gruber; Christina (Bad Vigaun, AT) Koller; Ulrich (Neumarkt am Wallersee, AT) 2032-11-02 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Bauer; Johann (Salzburg, AT) Gruber; Christina (Bad Vigaun, AT) Koller; Ulrich (Neumarkt am Wallersee, AT) 2032-11-02 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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