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Last Updated: October 1, 2020

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Patent: 9,650,684

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Summary for Patent: 9,650,684
Title:Methods of identifying and using general or alternative splicing inhibitors
Abstract: The present invention is based on the discovery of a cell-based system to identify novel modulators of splicing or splicing dependent processes. The cell-based system of the present invention utilizes a fast and highly sensitive reporter, that responds to defects in the splicing machinery itself and is sensitive to changes in the signals that regulate splicing dependent processes such as those that modulate the EJC, splicing-dependent export, localization or translation efficiency. The present invention further uses the cell-based screen to identify several small molecules that modulate both constitutive and alternative splicing. Accordingly, the present invention includes general or alternative splicing inhibitors identified using the assay described herein. The present invention also provides methods of treating a subject having a condition associated with aberrant target RNA expression. The present invention further details a kit that may be directed to specifically detecting a general or alternative splicing inhibitor of the invention.
Inventor(s): Dreyfuss; Gideon (Wynnewood, PA), Younis; Ihab (Philadelphia, PA), Wan; Lili (Westfield, NJ)
Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA)
Application Number:13/321,849
Patent Claims:see list of patent claims

Details for Patent 9,650,684

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial The Trustees of the University of Pennsylvania (Philadelphia, PA) 2029-05-22 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial The Trustees of the University of Pennsylvania (Philadelphia, PA) 2029-05-22 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial The Trustees of the University of Pennsylvania (Philadelphia, PA) 2029-05-22 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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