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Last Updated: September 30, 2020

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Patent: 9,649,316

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Summary for Patent: 9,649,316
Title:Induction of tumor hypoxia for cancer therapy
Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.
Inventor(s): Lee; Ruey-min (Ambler, PA), Lin; Peck-sun (Richmond, VA)
Assignee: Virginia Commonwealth University (Richmond, VA)
Application Number:14/043,661
Patent Claims:see list of patent claims

Details for Patent 9,649,316

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Start Trial Virginia Commonwealth University (Richmond, VA) 2039-02-26 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26   Start Trial Virginia Commonwealth University (Richmond, VA) 2039-02-26 RX Orphan search
Regeneron Pharmaceuticals EYLEA aflibercept INJECTABLE; INJECTION 125387 001 2011-11-18   Start Trial Virginia Commonwealth University (Richmond, VA) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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