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Generated: September 22, 2019

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Patent: 9,649,305

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Summary for Patent: 9,649,305
Title:PFKFB3 inhibitor and methods of use as an anti-cancer therapeutic
Abstract: A novel compound, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one- , is provided herein. (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) with surprisingly superior efficacy and pharmacodynamic properties in vitro and in vivo. Also provided are pharmaceutical compositions including the compound and methods of use of the compound in treating cancer and tumors in vivo, as well as inhibiting glycolytic flux and PFKFB3 enzymatic activity in cells. ##STR00001##
Inventor(s): Tapolsky; Gilles H. (Louisville, KY), Chand; Pooran (Birmingham, AL)
Assignee: Advanced Cancer Therapeutics, LLC (Louisville, KY)
Application Number:14/388,983
Patent Claims:see list of patent claims

Details for Patent 9,649,305

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Try a Free Trial Advanced Cancer Therapeutics, LLC (Louisville, KY) 2037-10-23 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Try a Free Trial Advanced Cancer Therapeutics, LLC (Louisville, KY) 2037-10-23 RX search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26   Try a Free Trial Advanced Cancer Therapeutics, LLC (Louisville, KY) 2037-10-23 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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