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Last Updated: October 4, 2022

Patent: 9,649,305


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Summary for Patent: 9,649,305
Title:PFKFB3 inhibitor and methods of use as an anti-cancer therapeutic
Abstract: A novel compound, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one- , is provided herein. (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) with surprisingly superior efficacy and pharmacodynamic properties in vitro and in vivo. Also provided are pharmaceutical compositions including the compound and methods of use of the compound in treating cancer and tumors in vivo, as well as inhibiting glycolytic flux and PFKFB3 enzymatic activity in cells. ##STR00001##
Inventor(s): Tapolsky; Gilles H. (Louisville, KY), Chand; Pooran (Birmingham, AL)
Assignee: Advanced Cancer Therapeutics, LLC (Louisville, KY)
Application Number:14/388,983
Patent Claims:see list of patent claims

Details for Patent 9,649,305

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Eli Lilly And Company ERBITUX cetuximab Injection 125084 02/12/2004 See Plans and Pricing 2039-02-26
Eli Lilly And Company ERBITUX cetuximab Injection 125084 03/28/2007 See Plans and Pricing 2039-02-26
Genentech, Inc. AVASTIN bevacizumab Injection 125085 02/26/2004 See Plans and Pricing 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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