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Patent: 9,636,420
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Summary for Patent: 9,636,420
| Title: | Polypeptide complex comprising non-peptidyl polymer having three functional ends |
| Abstract: | Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified. |
| Inventor(s): | Song; Dae Hae (Seoul, KR), Shin; Jae Hee (Suwon-si, KR), Lee; Mi Ji (Incheon, KR), Hong; Sung Hee (Suwon-si, KR), Kwon; Se Chang (Seoul, KR), Lee; Gwan Sun (Seoul, KR) |
| Assignee: | HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) |
| Application Number: | 13/055,406 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,636,420
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 004 | 2015-01-23 | Start Trial | HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) | 2028-07-23 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 003 | 2015-01-23 | Start Trial | HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) | 2028-07-23 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 002 | 2015-01-23 | Start Trial | HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) | 2028-07-23 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 001 | 2015-01-23 | Start Trial | HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) | 2028-07-23 | RX | Orphan | search |
| Microbix Biosystems | KINLYTIC | urokinase | INJECTABLE;INJECTION | 021846 | 003 | 1978-01-16 | Start Trial | HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) | 2028-07-23 | DISCN | search | |
| Microbix Biosystems | KINLYTIC | urokinase | INJECTABLE;INJECTION | 021846 | 002 | 1978-01-16 | Start Trial | HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) | 2028-07-23 | DISCN | search | |
| Microbix Biosystems | KINLYTIC | urokinase | INJECTABLE;INJECTION | 021846 | 001 | 1978-01-16 | Start Trial | HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) | 2028-07-23 | DISCN | search | |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 9,636,420
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| South Africa | 201100157 | Start Trial |
| World Intellectual Property Organization (WIPO) | 2010011096 | Start Trial |
| United States of America | 10071171 | Start Trial |
| United States of America | 2011200623 | Start Trial |
| United States of America | 2016051696 | Start Trial |
| United States of America | 2018360983 | Start Trial |
| Ukraine | 101670 | Start Trial |
| >Country | >Patent Number | >Estimated Expiration |
